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- 品牌：MedKoo
- 產(chǎn)地：美國
- 貨號(hào)：584817
- cas：1402936-61-1
- 發(fā)布日期： 2022-07-20
- 更新日期： 2024-08-12
| 產(chǎn)地 | 美國 |
| 品牌 | MedKoo |
| 貨號(hào) | 584817 |
| 用途 | This product is for research use only, not for human or veterinary use. |
| 包裝規(guī)格 | 1.0mg; 5.0mg; 10.0mg; 25.0mg; 50.0mg; 100.0mg; 200.0mg; |
| CAS編號(hào) | 1402936-61-1 |
| 純度 | >98%% |
| 是否進(jìn)口 | 是 |
Description: Runcaciguat, also known as BAY 1101042, is a novel, potent, and orally active sGC activator. Runcaciguat activated the sGC reporter cell line with an EC50 value of 11.2 ± 1.0 nM. Pretreatment of the sGC reporter cell line with 30 μM ODQ for 3 h resulted in an increased potency of runcaciguat (EC50 of 2.1 ± 0.07 nM), and treatment of the reporter cells with runcaciguat in combination with the NO donor S-nitroso-N-acetylpenicillamine (SNAP) (10 and 100 nM) showed additive effects. Treatment with runcaciguat resulted in maximal luminescence signals in the range of 50–60% in comparison to the sGC activator cinaciguat. Given the broad impact of oxidative stress in cardiovascular and cardiorenal diseases, runcaciguat might become a new treatment modality for a broad variety of diseases in these indication space but also beyond.
Name: Runcaciguat
CAS#: 1402936-61-1
Chemical Formula: C23H22Cl2F3NO3
Exact Mass: 487.0929
Molecular Weight: 488.33
Elemental Analysis: C, 56.57; H, 4.54; Cl, 14.52; F, 11.67; N, 2.87; O, 9.83
Synonym: Runcaciguat; BAY 1101042; BAY-1101042 BAY1101042;
IUPAC/Chemical Name: (3S)-3-{4-chloro-3-[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanamido]phenyl}-3-cyclopropylpropanoic acid
InChi Key: NCRMKIWHFXSBGZ-CNBXIYLPSA-N
InChi Code: InChI=1S/C23H22Cl2F3NO3/c1-12(23(26,27)28)21(14-4-7-16(24)8-5-14)22(32)29-19-10-15(6-9-18(19)25)17(11-20(30)31)13-2-3-13/h4-10,12-13,17,21H,2-3,11H2,1H3,(H,29,32)(H,30,31)/t12-,17+,21+/m1/s1
SMILES Code: O=C(O)C[C@H](C1=CC=C(Cl)C(NC([C@H](C2=CC=C(Cl)C=C2)[C@@H](C)C(F)(F)F)=O)=C1)C3CC3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
